Duration of Therapy - Indiana

by S. Kelly last updated 2021-02-08 20:35:52

Indiana State Department of Health

Duration of Therapy

Recommendations for Common Infectious Diseases

Infection Treatment Duration1
Cystitis 3-5 days
Pyelonephritis 7-14 days
Catheter-associated UTI 7-14 days
Acute Exacerbations of COPD
(when indicated)
5 days
Sinusitis (when indicated) 5 days
Community Acquired Pneumonia (CAP) 5 days
Hospital Acquired Pneumonia (HAP)/
Ventilator Associated Pneumonia (VAP)
7 days
Intra-abdominal infection (cholecystitis,
diverticulitis, peritonitis)
4-5 days
Clostridium difficile 10 days
Skin and Soft Tissue 5-7 days
Diabetic Foot Infections 7-21 days
Osteomyelitis

4-6 weeks
MRSA: 8 weeks

Bacteremia2 Uncomplicated MRSA: 14 days
Complicated MRSA: 4-6 weeks
Uncomplicated Gram-negative: 7 days
Other uncomplicated bacteremia: ~7-14 days

Notes

  1. Durations of treatment are highly patient specific and may vary depending on numerous factors. Those listed above are general recommendations from available clinical practice guidelines.
  2. ID consultation may be helpful to differentiate complicated vs. uncomplicated cases

References

  • Mermel LA, et al. Clinical practice guidelines for the diagnosis and management of intravascular catheter-related
    infections. Clin Infect Dis. 2009;49:1-45.
  • Metlay JP, Waterer GW, Long AC, et al. Diagnosis and treatment of adults with community-acquired pneumonia: an official clinical practice guidelines of the American Thoracic Society and Infectious Diseases Society of America. Am J Respir Crit Care Med. 2019; 200 (7): e45-67.
  • Kalil AC, Metersky ML, Klompas M, et al. Management of adults with hospital-acquired and ventilator-associated pneumonia: 2016 clinical practice guidelines by the Infectious Diseases Society of America and American Thoracic Society. Clin Infect Dis. 2016; 63(5): e61-111.
  • Stoller JK, et al. Clinical Practice. Acute exacerbations of chronic obstructive pulmonary disease. N Engl J Med.
    2002;346:988.
  • Solomin JS, et al. Diagnosis and management of complicated intra-abdominal infection in adults and children. Clin InfectDis. 2010;50:133-164.
  • McDonald LC, Gerding DN, Johnson S, et al. Clinical practice guidelines for Clostridium difficile infection in adults and children: 2017 update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA). Clin Infect Dis. 2018; 66(7): e1-48.
  • Stevens DL, et al. Practice guidelines for the diagnosis and management of skin and soft-tissue infections: 2014 update by the Infectious Diseases Society of America. Clin Infect Dis. 2014;59(2);147-59.
  • Lipsky BA, et al. 2012 Infectious Diseases Society of America: Diagnosis and treatment of diabetic foot infections. Clin Infect Dis. 2012;54(12):132-173.
  • Nicolle LE, Gupta K, Bradley S, et al. Clinical Practice Guideline for the management of asymptomatic bacteriuria: 2019 update by the Infectious Diseases Society of America. Clin Infect Dis. 2019; 68(10): 83-110.
  • Gupta K, et al. International clinical practice guidelines for the treatment of acute uncomplicated cystitis and Pyelonephritisin women: A 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases. Clin Infect Dis. 2011;52:e103.
  • Hooten TM, et al. Diagnosis, prevention, and treatment of catheter-associated urinary tract infection in adults: 2009 International clinical practice guidelines from the Infectious Diseases Society of America. Clin Infect Dis. 2010;50:62.